Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit

@inproceedings{BadiolaMateos2018ChallengesAF,
  title={Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit},
  author={Maider Badiola-Mateos and Arnau Hervera and Jos{\'e} Antonio Del R{\'i}o and J. Samitier},
  booktitle={Front. Bioeng. Biotechnol.},
  year={2018}
}
Movement of skeletal-muscle fibers is generated by the coordinated action of several cells taking part within the locomotion circuit (motoneurons, sensory-neurons, Schwann cells, astrocytes, microglia, and muscle-cells). Failures in any part of this circuit could impede or hinder coordinated muscle movement and cause a neuromuscular disease (NMD) or determine its severity. Studying fragments of the circuit cannot provide a comprehensive and complete view of the pathological process. We trace… CONTINUE READING
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