• Corpus ID: 7724116

Challenges ahead Electron Microscopy for Structural Biology from the Image Processing point of view

@article{Sorzano2017ChallengesAE,
  title={Challenges ahead Electron Microscopy for Structural Biology from the Image Processing point of view},
  author={Carlos Oscar S{\'a}nchez Sorzano and Jos{\'e} Mar{\'i}a Carazo},
  journal={ArXiv},
  year={2017},
  volume={abs/1701.00326}
}
Since the introduction of Direct Electron Detectors (DEDs), the resolution and range of macromolecules amenable to this technique has significantly widened, generating a broad interest that explains the well over a dozen reviews in top journal in the last two years. Similarly, the number of job offers to lead EM groups and/or coordinate EM facilities has exploded, and FEI (the main microscope manufacturer for Life Sciences) has received more than 100 orders of high-end electron microscopes by… 
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Computational methods for structure determination by single-particle cryo-EM and their guiding principles from statistical inference, machine learning, and signal processing that also play a significant role in many other data science applications are discussed.
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