Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo

@article{Dijkstra2006ChallengeWI,
  title={Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo},
  author={I. Dijkstra and A. H. de Haas and N. Brouwer and H. Boddeke and K. Biber},
  journal={Glia},
  year={2006},
  volume={54}
}
Since activated microglia are able to phagocytose damaged cells and subsequently express major histocompatibility complex class II (MHC‐II) and co‐stimulatory proteins, they are considered to function as antigen presenting cells (APCs) in the central nervous system. The maturation and migratory potential of professional APCs is associated with the expression of chemokine receptor CCR7. We therefore investigated whether the immunological activation of microglia induces CCR7 expression. We here… Expand
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