Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent

  title={Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent},
  author={P. Shukla and M. Satyanarayana and P. C. Verma and J. Tiwari and A. P. Dwivedi and Rohit Srivastava and Neha Rehuja and S. Srivastava and S. Gautam and A. Tamrakar and A. Dwivedi and H. N. Kushwaha and N. Gautam and Shio Kumar Singh and M. Srivastava and C. Nath and R. Raghubir and A. Srivastava and R. Pratap},
  journal={Current Science},
Poonam Shukla, Mavurapu Satyanarayana, Prem C. Verma, Jaya Tiwari, Atma P. Dwivedi, Rohit Srivastava, Neha Rehuja, Swayam P. Srivastava, Sudeep Gautam, Akhilesh K. Tamrakar, Anil K. Dwivedi, Hari N. Kushwaha, Nagsen Gautam, Shio K. Singh, Mukesh Srivastava, Chandishwar Nath, Ram Raghubir, Arvind K. Srivastava and Ram Pratap* Division of Medicinal and Process Chemistry, Division of Biochemistry, Division of Pharmaceutics, Division of Pharmacokinetics and Pharmaco-dynamics, Division of Biometry… Expand
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Bis- and mono-substituted Chalcones exert anti-feedant and toxic effects on fall armyworm Spodoptera frugiperda
The larvae fed with aggregate in the bis-chalcones diet had the highest percentage of intake and the poorest conversion of nutrient absorption (ECI), which suggests that the larva metabolizes food for energy and results in a decrease of growth and death in early stages. Expand
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Chalcones: A review on synthesis and pharmacological activities
of this article was presented at CUDC consortium and Summer School Conference at Chitkara University. ____________ Goyal et al. / Journal of Applied Pharmaceutical Science 11 (Supp 1); 2021: 001-014Expand
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Some chalcone compounds are synthesized and their characterization was done by spectroscopic techniques such as IR, NMR and mass spectrometry. Some physicochemical properties such as acousticalExpand


Flavone-based novel antidiabetic and antidyslipidemic agents.
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Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models
The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P < 0.01) in normal rats and shows around 17.7% (P < 0.01) and 17.1% fallExpand
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Synthesis and antidyslipidemic activity of chalcone fibrates.
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It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. Marsupium. Expand
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Pharmacokinetic stereoselectivity of troglitazone, an antidiabetic agent, in the KK mouse.
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The biological potential of flavones.
In this review, the roles of flavones in various metabolic and systemic disease models are discussed and their structure–activity relationships have generated interest among medicinal chemists. Expand