Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent

@article{Shukla2017ChalconeBasedAA,
  title={Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent},
  author={P. Shukla and M. Satyanarayana and P. C. Verma and J. Tiwari and A. P. Dwivedi and Rohit Srivastava and Neha Rehuja and S. Srivastava and S. Gautam and A. Tamrakar and A. Dwivedi and H. N. Kushwaha and N. Gautam and Shio Kumar Singh and M. Srivastava and C. Nath and R. Raghubir and A. Srivastava and R. Pratap},
  journal={Current Science},
  year={2017},
  volume={112},
  pages={1675}
}
Poonam Shukla, Mavurapu Satyanarayana, Prem C. Verma, Jaya Tiwari, Atma P. Dwivedi, Rohit Srivastava, Neha Rehuja, Swayam P. Srivastava, Sudeep Gautam, Akhilesh K. Tamrakar, Anil K. Dwivedi, Hari N. Kushwaha, Nagsen Gautam, Shio K. Singh, Mukesh Srivastava, Chandishwar Nath, Ram Raghubir, Arvind K. Srivastava and Ram Pratap* Division of Medicinal and Process Chemistry, Division of Biochemistry, Division of Pharmaceutics, Division of Pharmacokinetics and Pharmaco-dynamics, Division of Biometry… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Flavone-based novel antidiabetic and antidyslipidemic agents.
TLDR
The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice, and results indicate its association mainly with S isomers. Expand
Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models
The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P < 0.01) in normal rats and shows around 17.7% (P < 0.01) and 17.1% fallExpand
Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines.
TLDR
Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models. Expand
Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice.
TLDR
Results suggest that the antidiabetic effect of MC is derived, at least in part, from a decrease in insulin resistance because of the increase of GLUT4 protein content in the plasma membrane of the muscle. Expand
Synthesis and antidyslipidemic activity of chalcone fibrates.
TLDR
A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidsemic Syrian golden hamsters and the compounds 4c and 4f have been identified as most potent antidysipidemics. Expand
Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. and analysis of phytoconstituents.
TLDR
It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. Marsupium. Expand
Identification of novel urea derivatives as PTP1B inhibitors: synthesis, biological evaluation and structure–activity relationships
The protein tyrosine phosphatase 1B (PTP1B) is an attractive target for the treatment of type 2 diabetes. A series of substituted 1,3-benzyl urea has been synthesized and evaluated for PTP1BExpand
The antidiabetic activity of the herbal preparation ADD-199 in mice: a comparative study with two oral hypoglycaemic drugs.
TLDR
Antihyperglycaemic and antioxidant actions of ADD-199 at a dose of 100mg/kg/day are comparable to those of the maximum daily therapeutic doses of glibenclamide and metformin and could explain the basis for use of this plant extract to manage diabetes mellitus (DM). Expand
Pharmacokinetic stereoselectivity of troglitazone, an antidiabetic agent, in the KK mouse.
TLDR
The analysis of the plasma disposition after intravenous administration of troglitazone stereoisomers, using a kinetic model, indicated that the metabolic clearance in the liver showed a 2.5-fold maximum difference among stereoisomer and that the stereoselectivity of epimerization was low. Expand
The biological potential of flavones.
TLDR
In this review, the roles of flavones in various metabolic and systemic disease models are discussed and their structure–activity relationships have generated interest among medicinal chemists. Expand
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