Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens.

@article{Wagner2005ChalcogenoxanthyliumPF,
  title={Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens.},
  author={Stephen J Wagner and Andrey Skripchenko and David J. Donnelly and Krishna Ramaswamy and Michael R. Detty},
  journal={Bioorganic \& medicinal chemistry},
  year={2005},
  volume={13 21},
  pages={
          5927-35
        }
}
Selenorhodamine Photosensitizers for Photodynamic Therapy of P-Glycoprotein-Expressing Cancer Cells
TLDR
A synergistic therapeutic effect was observed when Colo-26 cells were exposed to PDT and treatment with the cancer drug doxorubicin, and selenorhodamine thioamide derivatives 16b and 18b were more effective photosensitizers than amide derivatives 15b and 17b.
Antimicrobial Effect of Photosensitized Rose Bengal on Bacteria and Viruses in Model Wash Water
TLDR
A visible light-activated photosensitizer, Rose Bengal (RB), is tested for the reduction of microbial load in simulated wash water and its potential as an alternative sanitizer for the food industry is demonstrated.
The application of photosensitisers to tropical pathogens in the blood supply.
From seconds to femtoseconds: solar hydrogen production and transient absorption of chalcogenorhodamine dyes.
TLDR
The selenium-containing species is the only dye for which triplet state population is significant, which explains its superior activity in hydrogen evolution, and demonstrates the importance of understanding the differences between, as well as the effects of the conditions for DSSCs and solar hydrogen production.
Trends and targets in antiviral phototherapy.
  • A. Wiehe, Jessica M O'Brien, M. Senge
  • Biology, Medicine
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2019
TLDR
This review focuses on the PDI of viruses as an alternative treatment in antiviral therapy, but also as a means of viral decontamination, covering mainly the literature of the last decade.
Use of a Red Cell Band 3-Ligand/Antioxidant to Improve Red Cell Storage Properties Following Virucidal Phototeatment with Chalcogenoxanthylium Photosensitizers
TLDR
Red cell binding studies revealed only a small degree of competition betweenDP and TMR-S, and no competition between DP with DJD-42 for binding to red cell membranes, suggesting that protection of red cells by DP in this system may primarily stem from its antioxidant properties.
Biological and Biochemical Aspects of Tellurium Derivatives
TLDR
Low molecular weight organotellurium compounds that mimic glutathione peroxidase and the thioredoxin reductases are discussed as are inorganic and organic tellurium compound that inhibit cysteine proteases and related enzymes.
Synthesis and Properties of Heavy Chalcogen Analogues of the Texas Reds and Related Rhodamines
Analogues of Texas red incorporating the heavy chalcogens S, Se, and Te atoms in the xanthylium core were prepared from the addition of aryl Grignard reagents to appropriate chalcogenoxanthone
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.
TLDR
In MDCKII-MDR1 cells, the tertiary thioamide- containing derivatives promote uptake of calcein AM and have very slow passive, absorptive, and secretory rates of transport relative to transport rates for tertiary amide-containing derivatives.
...
...

References

SHOWING 1-10 OF 31 REFERENCES
Comparison of Methylene Blue and Methylene Violet for Photoinactivation of Intracellular and Extracellular Virus in Red Cell Suspensions
TLDR
Results indicate that the uncharged phenothiazine dye, MV, can inactivate both intracellular and extracellular virus yet exhibit similar in vitro red cell storage properties as MB phototreatment.
Factors Affecting Virus Photoinactivation by a Series of Phenothiazine Dyes
TLDR
The high affinity of 1,9‐di‐methyymethylene blue for DNA and the dye's efficient singlet oxygen yield suggest viral nucleic acid as a potential target, which could explain the photosensitizer's ability to inactivate viruses without adversely affecting anuclete red cells.
ANALYSIS OF VIRAL DNA, PROTEIN AND ENVELOPE DAMAGE AFTER METHYLENE BLUE, PHTHALOCYANINE DERIVATIVE OR MEROCYANINE 540 PHOTOSENSITIZATION
TLDR
It is suggested that nucleic acid may be an important target for photoinactivation of these model viruses by MB and AlPcS4 and phototreatment of M13 bacteriophage and vesicular stomatitis virus.
Quinacrine Enhances Vesicular Stomatitis Virus Inactivation and Diminishes Hemolysis of Dimethylmethylene Blue–phototreated Red Cells¶
TLDR
It is suggested that despite its recognized affinity for viral nucleic acid, DMMB also binds to RBC membranes and that the bound dye is, in part, responsible for photoinduced hemolysis.
Red cell alterations associated with virucidal methylene blue phototreatment
TLDR
Data suggest that the red cell surface is altered by virucidal MB phototreatment of vesicular stomatitis virus.
...
...