Chain length is the main determinant of the folding rate for proteins with three-state folding kinetics.

@article{Galzitskaya2003ChainLI,
  title={Chain length is the main determinant of the folding rate for proteins with three-state folding kinetics.},
  author={Oxana V. Galzitskaya and Sergiy O. Garbuzynskiy and Dmitry N. Ivankov and Alexei V. Finkelstein},
  journal={Proteins},
  year={2003},
  volume={51 2},
  pages={162-6}
}
We demonstrate that chain length is the main determinant of the folding rate for proteins with the three-state folding kinetics. The logarithm of their folding rate in water (k(f)) strongly anticorrelates with their chain length L (the correlation coefficient being -0.80). At the same time, the chain length has no correlation with the folding rate for two-state folding proteins (the correlation coefficient is -0.07). Another significant difference of these two groups of proteins is a strong… CONTINUE READING

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