Chain length-dependent association of distamycin-type oligopeptides with A X T and G X C pairs in polydeoxynucleotide duplexes.

@article{Zimmer1983ChainLA,
  title={Chain length-dependent association of distamycin-type oligopeptides with A X T and G X C pairs in polydeoxynucleotide duplexes.},
  author={Christian Zimmer and G. Luck and Eckhard Birch-Hirschfeld and Raymond Weiss and Federico Arcamone and W. Guschlbauer},
  journal={Biochimica et biophysica acta},
  year={1983},
  volume={741 1},
  pages={15-22}
}
Different binding affinities of various distamycin analogs including the deformylated derivative with poly(dA-dC) X poly(dG-dT) were investigated using CD measurements. The inhibitory effect of distamycins on the DNAase I cleavage activity of DNA duplexes strongly supports the binding data. The base specificity of the ligand interaction with duplex DNA depends on the chain length of distamycin analogs. Netropsin, distamycin-2 and the deformylated distamycin-3 show no binding to dG X dC… CONTINUE READING

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