Chagas disease 101

  title={Chagas disease 101},
  author={Julie Clayton},
It is 101 years since Carlos Chagas discovered the parasite responsible for the disease that now bears his name. What progress has been made since this discovery? Here Julie Clayton gives the low-down on Chagas disease. 

Was Chagas disease responsible for Darwin’s illness? The overlooked eco-epidemiological context in Chile

According to his diary and letters, during his overland trips, Darwin slept in rural houses and outdoors for 128 days in a “hyperendemic” area for Chagas disease, more than exposing him to kissing bugs, conveys a likely additional source of infection than previously considered, which might reinforce the idea that ChagAs disease contributed to Darwin’s manifest physical deterioration.

Atividade de amidinas aromáticas sobre Trypanosoma Cruzi: estudos in vitro e in vivo

Fundacao Carlos Chagas Filho de Amparo, Conselho Nacional Desenvolvimento Cientifico e Tecnologico,PAPES V/FIOCRUZ,Consortium for Parasitic Drug Development

Estudio preliminar de la miocarditis chagásica aguda experimental y su relación con la administración de esteroides sexuales

La infeccion aguda por Trypanosoma cruzi (T. cruzi) en ratas adultas cursa con una parasitemia poco evident...

The urgent need to develop new drugs and tools for the treatment of Chagas disease

The compulsory screening of T. cruzi in hemoderivatives and solid organs donated by patients from Latin America should be considered, because there are large numbers of South American immigrants who are often unaware of their infection, which has serious public health implications for the management of blood banks and healthcare provision.

Medicinal organometallic compounds with anti-chagasic activity

This paper reviews the latest advances in the design of organometallic compounds that proved to be active against CD and a number of potential metal-based antiparasitic drugs have been reported.

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.

The first enantioselective chemical synthesis of VNI (at a materials cost of less than $0.10/mg) is described and the key enantiOSElective step is performed at the 10 g scale.

Targeting the Gut Microbiota in Chagas Disease: What Do We Know so Far?

An enhanced understanding of host microbiota will be critical for the development of alternative therapeutic approaches to target CD, such as gut microbiota-directed interventions, and discusses its importance for CD pathogenesis.

Interstitial cells of Cajal: crucial for the development of megacolon in human Chagas' disease?

Megacolon, chronic dilation of a colonic segment,is accompanied by extensive myenteric neuron loss. However, this fails to explain unequivocally the formation of megacolon. We aimed to study further

Identification of small-molecule inhibitors of Trypansoma cruzi replication.




Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela.

This outbreak was unique,Because it affected a large, urban, predominantly young, middle-class, otherwise healthy population and resulted in an unprecedented public health emergency, rapid diagnosis and treatment avoided higher lethality.

Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic chagas heart disease.

The role of the parasite in pathogenesis and disease progression of chronic Chagas heart disease was associated with persistence of parasite DNA in cardiac lesions of necropsies or explants from Argentinean cChHD patients.

Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathy.

These studies demonstrate that T. cruzi, or a portion of its genome, is present in the inflammatory lesion of chronic cardiac Chagas' disease.

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