Chagas' disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods.

@article{Gomes1999ChagasDD,
  title={Chagas' disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods.},
  author={Maria Luisa Gomes and L{\'u}cia Maria da Cunha Galv{\~a}o and A. M. S. Mac{\^e}do and S{\'e}rgio D. Junho Pena and Egler Chiari},
  journal={The American journal of tropical medicine and hygiene},
  year={1999},
  volume={60 2},
  pages={205-10}
}
During the course of chronic chagasic infection, low parasitemia levels prevent parasite detection by current techniques such as hemoculture and xenodiagnosis. Since serologic tests have sensitivity but lack specificity, molecular assays based on the polymerase chain reaction (PCR) have been proposed as alternative tools for parasite detection in individuals with chronic Chagas' disease. A variable degree of PCR efficiency has been reported in the literature and illustrates the need for further… CONTINUE READING

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