ChT1, an Ig superfamily molecule required for T cell differentiation.


The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development.

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@article{Katevuo1999ChT1AI, title={ChT1, an Ig superfamily molecule required for T cell differentiation.}, author={Kalevi Katevuo and Beat Albert Imhof and Richard L. Boyd and Ann P. Chidgey and Andrew G. Bean and Dominique Dunon and Thomas W. F. G{\"{o}bel and Olli Vainio}, journal={Journal of immunology}, year={1999}, volume={162 10}, pages={5685-94} }