ChIPing the cistrome of PXR in mouse liver

  title={ChIPing the cistrome of PXR in mouse liver},
  author={Julia Yue Cui and Sumedha S. Gunewardena and Cheryl E Rockwell and Curtis D. Klaassen},
  booktitle={Nucleic acids research},
The pregnane X receptor (PXR) is a key regulator of xenobiotic metabolism and disposition in liver. However, little is known about the PXR DNA-binding signatures in vivo, or how PXR regulates novel direct targets on a genome-wide scale. Therefore, we generated a roadmap of hepatic PXR bindings in the entire mouse genome [chromatin immunoprecipitation (ChIP)-Seq]. The most frequent PXR DNA-binding motif is the AGTTCA-like direct repeat with a 4 bp spacer [direct repeat (DR)-4)]. Surprisingly… CONTINUE READING

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