ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

@inproceedings{Chung2014ChIPseqAI,
  title={ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence},
  author={Dawoon Chung and Bridget Marie Barker and Charles C. Carey and Brittney Merriman and Ernst R Werner and Beatrix Elisabeth Lechner and Sourabh Dhingra and Chao Cheng and Wenjie Xu and Sara J. Blosser and Kengo Morohashi and Aur{\'e}lien Mazurie and Thomas K. Mitchell and Hubertus Haas and Aaron P. Mitchell and Robert A Cramer},
  booktitle={PLoS pathogens},
  year={2014}
}
The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence in murine models of invasive pulmonary aspergillosis (IPA). How fungal SREBPs mediate fungal virulence is unknown, though it has been suggested that lack of growth in hypoxic… CONTINUE READING
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Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA

  • FM Soriani, I Malavazi, MED Ferreira, M Savoldi, MRV Kress
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