ChIP-chip comes of age for genome-wide functional analysis.

Abstract

In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project.

1 Figure or Table

0200400'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

1,039 Citations

Semantic Scholar estimates that this publication has 1,039 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wu2006ChIPchipCO, title={ChIP-chip comes of age for genome-wide functional analysis.}, author={Jiejun Wu and Laura T. Smith and Christoph Plass and Tim Hui-Ming Huang}, journal={Cancer research}, year={2006}, volume={66 14}, pages={6899-902} }