ChIP-chip comes of age for genome-wide functional analysis.


In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project.

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@article{Wu2006ChIPchipCO, title={ChIP-chip comes of age for genome-wide functional analysis.}, author={Jiejun Wu and Laura T. Smith and Christoph Plass and Tim Hui-Ming Huang}, journal={Cancer research}, year={2006}, volume={66 14}, pages={6899-902} }