ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder.

  title={ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder.},
  author={Leelavati Narlikar and Raja Jothi},
  journal={Methods in molecular biology},
Protein-DNA interactions play key roles in determining gene-expression programs during cellular development and differentiation. Chromatin immunoprecipitation (ChIP) is the most widely used assay for probing such interactions. With recent advances in sequencing technology, ChIP-Seq, an approach that combines ChIP and next-generation parallel sequencing is fast becoming the method of choice for mapping protein-DNA interactions on a genome-wide scale. Here, we briefly review the ChIP-Seq approach… CONTINUE READING
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