ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions

@article{Furey2012ChIPseqAB,
  title={ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions},
  author={Terrence S. Furey},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={840-852}
}
Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect protein–DNA binding events and chemical modifications of histone proteins. Challenges in the standard ChIP–seq protocol have motivated recent enhancements in this approach, such as reducing the number of cells that are required and increasing the resolution. Complementary experimental approaches — for example, DNaseI hypersensitive site mapping and analysis of chromatin interactions that are mediated by… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 19 times over the past 90 days. VIEW TWEETS
182 Citations
111 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 182 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 111 references

DNase I sensitivity QTLs are a major determinant of human expression variation

  • Degner, F J.
  • Nature 482,
  • 2012

Similar Papers

Loading similar papers…