ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

@article{Lachmann2010ChEATF,
  title={ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments},
  author={Alexander Lachmann and Huilei Xu and Jayanth Krishnan and Seth I. Berger and Amin R. Mazloom and Avi Ma'ayan},
  journal={Bioinformatics},
  year={2010},
  volume={26 19},
  pages={2438-44}
}
MOTIVATION Experiments such as ChIP-chip, ChIP-seq, ChIP-PET and DamID (the four methods referred herein as ChIP-X) are used to profile the binding of transcription factors to DNA at a genome-wide scale. Such experiments provide hundreds to thousands of potential binding sites for a given transcription factor in proximity to gene coding regions. RESULTS In order to integrate data from such studies and utilize it for further biological discovery, we collected interactions from such experiments… CONTINUE READING
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