Cgrp May Play A Causative Role in Migraine

  title={Cgrp May Play A Causative Role in Migraine},
  author={L. Lassen and P. A. Haderslev and V. Jacobsen and H. Iversen and B. Sperling and J. Olesen},
  pages={54 - 61}
  • L. Lassen, P. A. Haderslev, +3 authors J. Olesen
  • Published 2002
  • Medicine
  • Cephalalgia
  • Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in external jugular venous blood during migraine attacks. However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache. In a double-blind crossover study, the effect of human αCGRP (2 μg/min) or placebo infused intravenously for 20 min was studied in 12 patients suffering from migraine without aura. Headache intensity was scored on a scale from 0 to 10. Two patients were excluded due… CONTINUE READING
    688 Citations

    Topics from this paper

    Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
    • 238
    • Highly Influenced
    The Headache-Inducing Effect of Cilostazol in Human Volunteers
    • 64
    Prostaglandin E2 induces immediate migraine-like attack in migraine patients without aura
    • 30
    No increase of calcitonin gene–related peptide in jugular blood during migraine
    • 162
    Calcitonin gene related peptide (CGRP)–provoked migraine-like attacks
    • 4
    • PDF
    PACAP38 induces migraine-like attacks in patients with migraine without aura.
    • 262
    • Highly Influenced
    • PDF


    A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks
    • 259
    Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
    • 394
    The Nitric Oxide Hypothesis of Migraine and Other Vascular Headaches
    • 222