Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.

  title={Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.},
  author={Adam Navis and Lindsay Marjoram and Michel Bagnat},
  volume={140 8},
Regulated fluid secretion is crucial for the function of most organs. In vertebrates, the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) is a master regulator of fluid secretion. Although the biophysical properties of CFTR have been well characterized in vitro, little is known about its in vivo role during development. Here, we investigated the function of Cftr during zebrafish development by generating several cftr mutant alleles using TAL effector nucleases. We… CONTINUE READING


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