Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.

@article{Navis2013CftrCL,
  title={Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.},
  author={Adam Navis and Lindsay Marjoram and Michel Bagnat},
  journal={Development},
  year={2013},
  volume={140 8},
  pages={1703-12}
}
Regulated fluid secretion is crucial for the function of most organs. In vertebrates, the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) is a master regulator of fluid secretion. Although the biophysical properties of CFTR have been well characterized in vitro, little is known about its in vivo role during development. Here, we investigated the function of Cftr during zebrafish development by generating several cftr mutant alleles using TAL effector nucleases. We… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Kupffer's vesicle size threshold for robust left-right patterning of the zebrafish embryo.

Developmental dynamics : an official publication of the American Association of Anatomists • 2016
View 14 Excerpts
Highly Influenced

Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies.

Current topics in developmental biology • 2017
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Similar Papers

Loading similar papers…