Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

@article{Luong2013CezanneRI,
  title={Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.},
  author={Le Anh Luong and Maria Fragiadaki and Jennifer Bengston Smith and Joseph S Boyle and Jens Lutz and Jonathan L. E. Dean and Sarah K. Harten and Margaret Ashcroft and Sarah R Walmsley and Dorian O. Haskard and Patrick Henry Maxwell and Henning Walczak and Charles Dickson Pusey and Paul C. Evans},
  journal={Circulation research},
  year={2013},
  volume={112 12},
  pages={1583-91}
}
RATIONALE Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms that suppress tumor necrosis factor receptor-associated factor 6 ubiquitination are potential therapeutic targets to reduce inflammation in hypoxic tissues. OBJECTIVE In this study… CONTINUE READING
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