Cetuximab use without chronic antihistamine premedication.

  title={Cetuximab use without chronic antihistamine premedication.},
  author={John P Timoney and Ki Young Chung and Vivian J Park and Robin Trocola and C Peake and Leonard Saltz},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={24 18_suppl},
13521 Background: Cetuximab is a human-murine chimeric monoclonal antibody against EGFR with approximately a 3% reported incidence of severe (≥ grade 3) anaphylactoid reactions. The overwhelming majority of such reactions have been reported with the initial dose of cetuximab. Diphenhydramine (Benedryl)or a related antihistamine is often given as a premedication for cetuximab, however this may cause fatigue or other side effects. Most early clinical trials of cetuximab permitted investigator… CONTINUE READING