Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.

@article{Chung2008CetuximabinducedAA,
  title={Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.},
  author={Christine H. Chung and Beloo Mirakhur and Emily T Chan and Quynh-Thu Le and Jordan D. Berlin and Michael S. Morse and Barbara A. Murphy and Shama M Satinover and Jacob D Hosen and Dave M. Mauro and Robert J. C. Slebos and Qinwei Zhou and Diane R. Gold and Tina K Hatley and Daniel J. Hicklin and Thomas A E Platts-Mills},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 11},
  pages={
          1109-17
        }
}
BACKGROUND Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against the epidermal growth factor receptor, is approved for use in colorectal cancer and squamous-cell carcinoma of the head and neck. A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States. METHODS We analyzed serum samples from four groups of subjects for IgE antibodies against cetuximab: pretreatment samples from 76 case subjects who had been treated with… CONTINUE READING
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