Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids

@inproceedings{Kloess2015CetuximabRP,
  title={Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids},
  author={Stephan Kloess and Nicole Chambron and Tanja Gardlowski and Sandra Weil and Joachim Koch and Ruth Esser and Elke Pogge von Strandmann and Michael Graham Morgan and Lubomir Arseniev and Oliver Seitz and Ulrike Koehl},
  booktitle={Front. Immunol.},
  year={2015}
}
Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for therapeutic intervention. In order to overcome TIEMs, we investigated the antibody-dependent cellular cytotoxicity (ADCC), cytokine release and retargeted tumor infiltration of sMICA… CONTINUE READING
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