Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial.

@article{Kurtz2009CetuximabTA,
  title={Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial.},
  author={Jean Emmanuel Kurtz and A-C Hardy-Bessard and Marion Deslandres and Sandrine Lavau-Denes and R{\'e}my Largillier and C{\'e}lia Roemer-Becuwe and B{\'e}atrice Weber and C{\'e}cile Guillemet and D{\'e}sir{\'e} Paraiso and {\'E}ric Pujade-Lauraine},
  journal={Gynecologic oncology},
  year={2009},
  volume={113 1},
  pages={16-20}
}
OBJECTIVE Cisplatin (Cp) plus topotecan (Tc) is the first combination chemotherapy to demonstrate a survival advantage over cisplatin alone in advanced cervical cancer. Combining Cp and Tc with an epidermal growth factor receptor (EGFR) inhibitor such as cetuximab (Ce) may increase the activity of chemotherapy. METHODS Patients with advanced cervical squamous cell cancer or adenocarcinoma and at least one measurable target received intravenous Cp 50 mg/m(2) on day 1 plus Tc 0.75 mg/m(2)/day… CONTINUE READING

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