Cetirizine in horses: pharmacokinetics and pharmacodynamics following repeated oral administration.

@article{Olsn2008CetirizineIH,
  title={Cetirizine in horses: pharmacokinetics and pharmacodynamics following repeated oral administration.},
  author={Lena Ols{\'e}n and U. G. Bondesson and Hans Brostr{\"o}m and Hans Tj{\"a}lve and Carina Ingvast-Larsson},
  journal={Veterinary journal},
  year={2008},
  volume={177 2},
  pages={242-9}
}
The pharmacokinetics of the histamine H(1)-antagonist cetirizine and its effect on histamine-induced cutaneous wheal formation were studied in six healthy horses following repeated oral administration. After three consecutive administrations of cetirizine (0.2 mg/kg body weight, bw) every 12h, the trough plasma concentration of cetirizine was 16+/-4 ng/mL (mean+/-SD) and the wheal formation was inhibited by 45+/-23%. After four additional administrations of cetirizine (0.4 mg/kg bw) every 12 h… CONTINUE READING