Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats.

@article{Yamada2008CetilistatA,
  title={Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats.},
  author={Y. Yamada and T. Kato and H. Ogino and S. Ashina and K. Kato},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2008},
  volume={40 8},
  pages={
          539-43
        }
}
  • Y. Yamada, T. Kato, +2 authors K. Kato
  • Published 2008
  • Medicine, Biology
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • Cetilistat is a novel inhibitor of pancreatic lipase. The aim of this report is to evaluate the anti-obesity action of cetilistat in diet-induced obesity (DIO) rats. Cetilistat inhibited rat and human pancreatic lipase activity with an IC (50) of 54.8 nmol/l, and 5.95 nmol/l, respectively, meaning that it is 9.2 times more potent for human pancreatic lipase than for that of rat. Cetilistat was orally administered simultaneously with fat emulsion to Sprague-Dawley rats. Plasma triglyceride (TG… CONTINUE READING
    Epidemiology of Obesity and Pharmacologic Treatment Options
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