Cessation of cell proliferation by adjustment of cell redox potential.

  title={Cessation of cell proliferation by adjustment of cell redox potential.},
  author={Arnold Hoffman and Lee M Spetner and Michael Burke},
  journal={Journal of theoretical biology},
  volume={211 4},
A variety of chemical substances are known to stop cell proliferation, although the mechanisms are obscure. We suggest that many of these chemicals employ the braking power of the retinoblastoma (RB) protein to stop proliferation by raising the intracellular redox potential. The elevation of the redox potential above a threshold prevents the phosphorylation of RB protein, which in turn impedes the release of transcription factors necessary for the progression of the cell cycle. The redox… CONTINUE READING

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