Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.

@article{Herold2005CervimycinAA,
  title={Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.},
  author={Kerstin Herold and Friedrich A Gollmick and Ingrid Groth and M. Roth and Klaus-Dieter Menzel and Ute Moellmann and Udo Graefe and Christian Hertweck},
  journal={Chemistry},
  year={2005},
  volume={11 19},
  pages={5523-30}
}
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of… CONTINUE READING

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