Cervical ultrasound and computed tomography of Kawasaki disease: Comparison with lymphadenitis.


BACKGROUND Differentiating Kawasaki disease (KD) from cervical lymphadenitis (CL) is clinically difficult but essential given that treatment and outcome differ significantly. Research on differentiation between KD and CL using ultrasound (US) and computed tomography (CT) is limited. The purpose of this study was to identify cervical US and CT findings that may differentiate KD from CL. METHODS We retrospectively reviewed cervical US of 25 KD patients and 25 CL patients, and CT of 14 KD patients, and 14 CL patients. Two radiologists analyzed specific imaging features on US (lymph node size, shape, echogenicity, margins, laterality, necrosis, and presence of normal hilum) and on CT (size and location of enlarged nodes, laterality, perinodal infiltration, and retropharyngeal edema). RESULTS On US, patients with KD more frequently had lymph nodes with a "cluster of grapes" appearance (KD vs CL: 64% vs 32%, P < 0.05) and less frequently had poorly circumscribed margins (0% vs 36%, P < 0.01), necrosis (0% vs 32%, P < 0.01), or non-visualization of the hilum (4% vs 36%, P < 0.01). On CT, KD patients more frequently had retropharyngeal edema (100% vs 29%, P < 0.001) and less frequently had level 4 lymphadenopathy (14% vs 79%, P < 0.01) than CL patients. CONCLUSIONS Ultrasound is mainly useful for excluding purulent lymphadenopathy while CT is a useful diagnostic tool for differentiating KD from CL, especially in patients with incomplete KD, who present with prominent cervical lymphadenopathy and other equivocal principal findings.

DOI: 10.1111/ped.13017

Cite this paper

@article{Nozaki2016CervicalUA, title={Cervical ultrasound and computed tomography of Kawasaki disease: Comparison with lymphadenitis.}, author={Taiki Nozaki and Yuka Morita and Daisuke Hasegawa and Akari Makidono and Yuri Yoshimoto and Jay Starkey and Isao Kusakawa and Atsushi Manabe and Yukihisa Saida}, journal={Pediatrics international : official journal of the Japan Pediatric Society}, year={2016}, volume={58 11}, pages={1146-1152} }