Cervical carcinoma and reproductive factors: Collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies

@article{Dillner2006CervicalCA,
  title={Cervical carcinoma and reproductive factors: Collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies},
  author={Joakim Dillner and Ilvars Silins},
  journal={International Journal of Cancer},
  year={2006},
  volume={119}
}
The International Collaboration of Epidemiological Studies of Cervical Cancer has combined individual data on 11,161 women with invasive carcinoma, 5,402 women with cervical intraepithelial neoplasia (CIN)3/carcinoma in situ and 33,542 women without cervical carcinoma from 25 epidemiological studies. Relative risks (RRs) and 95% confidence intervals (CIs) of cervical carcinoma in relation to number of full‐term pregnancies, and age at first full‐term pregnancy, were calculated conditioning by… 
Cervical Carcinoma and Sexual Behavior: Collaborative Reanalysis of Individual Data on 15,461 Women with Cervical Carcinoma and 29,164 Women without Cervical Carcinoma from 21 Epidemiological Studies
TLDR
CIN3/carcinoma in situ showed a similar association with lifetime number of sexual partners; however, the association with age at first intercourse was weaker than for invasive carcinoma.
Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: Collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies
TLDR
The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374Women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies to assess risk factors for these histological types.
Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16 573 women with cervical cancer and 35 509 women without cervical cancer from 24 epidemiological studies
TLDR
The relative risk of cervical cancer is increased in current users of oral contraceptives and declines after use ceases, and by 10 or more years had returned to that of never users.
Time since first sexual intercourse and the risk of cervical cancer
TLDR
It is suggested that HPV vaccination may prevent the majority of cervical cancers by delaying HPV infection without necessarily providing lifetime protection against HPV.
The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort
TLDR
The results suggest that several hormonal factors are risk factors for cervical carcinogenesis and adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.
Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
TLDR
Childbirth increases the risk for subsequent CIN3+ among women with persistent HPV infection, and no association was found with pregnancy, use of intrauterine devices, or sexual behaviour.
Ranking lifestyle risk factors for cervical cancer among Black women: A case-control study from Johannesburg, South Africa
TLDR
Cervical cancer in decreasing order of priority was associated with being HIV positive, and this rank order of risks could be used to target educational messaging and appropriate interventions for cervical cancer prevention in South African women.
Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case‐control study in the Swiss HIV cohort study
TLDR
In conclusion, worsening immunodeficiency, even at only moderately decreased CD4+ cell counts, is a significant risk factor for CIN2/3 and cervical cancer.
Short-term risk of cervical intraepithelial neoplasia grades 2 and 3 for women with normal cytology and human papillomavirus infection.
TLDR
Short-term absolute risk of CIN2/3+ after a normal Pap smear with concurrent HR-HPV infection is low, suggesting that the HR- HPV test has limited utility in short-term clinical decision-making for women with normal cytology.
The role of co-factors in the progression from human papillomavirus infection to cervical cancer.
TLDR
Differences in established risk factors suggest that CIN3 is a more specific definition of cervical cancer than CIN2, and hormonally-related factors and smoking play a role in the transition from human papillomavirus infection to precancer.
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