Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense

@article{So2018CervicalCI,
  title={Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense},
  author={Daeho So and Hyun-Woo Shin and Jiyoung Kim and Mingyu Lee and Jongyun Myeong and Yang-Sook Chun and Jong-Wan Park},
  journal={Oncogene},
  year={2018},
  volume={37},
  pages={5191-5204}
}
Mammalian cells are equipped with antiviral innate immunity. [] Key Result SIRT1-knocked-down cells showed representative features of pyroptosis, as well as highly expressed absent in melanoma 2 (AIM2) and its downstream genes related to the inflammasome response. Mechanistically, SIRT1 repressed the NF-κB-driven transcription of the AIM2 gene by destabilizing the RELB mRNA.

The complex role of AIM2 in autoimmune diseases and cancers

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