Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense

  title={Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense},
  author={Daeho So and Hyun-Woo Shin and Jiyoung Kim and Mingyu Lee and Jongyun Myeong and Yang-Sook Chun and Jong-Wan Park},
Mammalian cells are equipped with antiviral innate immunity. [] Key Result SIRT1-knocked-down cells showed representative features of pyroptosis, as well as highly expressed absent in melanoma 2 (AIM2) and its downstream genes related to the inflammasome response. Mechanistically, SIRT1 repressed the NF-κB-driven transcription of the AIM2 gene by destabilizing the RELB mRNA.

The complex role of AIM2 in autoimmune diseases and cancers

An overview of the emerging research progress on the function and regulatory pathway of AIM2 in innate and adaptive immune cells, as well as tumor cells, and its pathogenic role in autoimmune diseases and cancers are discussed, hopefully providing potential therapeutic and diagnostic strategies for clinical use.

Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway

The results demonstrated that tanshinone II A regulated cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway, which provides a novel therapy for the treatment of cervical cancer.

Absent in melanoma 2 suppresses epithelial‐mesenchymal transition via Akt and inflammasome pathways in human colorectal cancer cells

Migration, invasion ability, and epithelial‐mesenchymal transition (EMT) program upon AIM2 overexpression or knockdown in human CRC cells were assessed and it was shown that upregulation of A IM2 reduced cell migration and invasion.

Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3

SIRT1 promoted autophagy and proliferation of EC cells by reducing acetylation level of LC3, which is a member of histone deacetylase, which extensively participates in the progression of aging, cell death, and tumorigenesis.

Extracellular Vesicles Long Non-Coding RNA AGAP2-AS1 Contributes to Cervical Cancer Cell Proliferation Through Regulating the miR-3064-5p/SIRT1 Axis

It is concluded that EV lncRNA AGAP2-AS1 contributed to cervical cancer cell proliferation through regulating the miR-3064-5p/SIRT1 axis.

Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.

The proliferation of breast cancer cells was inhibited after lentivirus infection with sh-SIRT1, showing that SIRT1 was significant greatly expressed in breast cancer.

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

This review summarizes knowledge of the reciprocal interaction between antitumor immunity and distinct cell death mechanisms, particularly necroptosis, ferroPTosis, and pyroaptosis, which are the three potentially novel mechanisms of immunogenic cell death.

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

The role of pyroPTosis in cancer progression and the modulation of immunity is elucidated and the potential small molecules and nanomaterials that target pyroptotic cell death mechanisms and their therapeutic effects on cancer are summarized.

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

This review summarizes the multilevel relationship between antitumor immunity and non-apoptotic RCD, including autophagy, ferroPTosis, pyroptosis, and necroptosis; and the potential targeting application of non-APoptosis RCD to improve the efficacy of immunotherapy in malignancy.

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

Induced pyroptosis may play a predominant role in the treatment of cancer, and appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherAPEutic drugs and reducing drug resistance.



HPV16 activates the AIM2 inflammasome in keratinocytes

Novel aspects concerning HPV-induced innate immune responses were identified and crosstalk between IFI16 and AIM2 in the immune response to HPV DNA is suggested, which could lead to the development of novel strategies for the prevention and treatment of HPV infections.

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

AIM2 reduced Akt activation and tumor burden in colorectal cancer models, while an Akt inhibitor reduced tumor load in Aim2−/− mice, suggesting that Akt inhibitors could be used to treat AIM2-deficient human cancers.

Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells

Evidence is presented that SIRT1, an aging-related NAD-dependent deacetylase, mediates HPV E7 survival function in SiHa cervical cancer cells and this link may open the way for a more in-depth understanding of the process of HPV-induced malignant transformation and the inter-relationships between aging and cancer.

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

It is suggested that AIM2 played a critical role as a tumor suppressor and might serve as a potential therapeutic target for future development of A IM2-based gene therapy for human liver cancer.

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

It is demonstrated that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone deacetylase, regulates the transcriptional activity of NF‐κB and activity augments apoptosis in response to TNFα.

AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

It is shown that AIM2 expression suppressed the proliferation and tumorigenicity of human breast cancer cells, and that A IM2 gene therapy inhibited mammary tumor growth in an orthotopic tumor model, suggesting that Aim2 associates with tumor suppression activity.

The Effects of siRNA SIRT1 on the Proliferation of Human Cervical Cancer Cells

SIRT1 siRNA could down-regulate the expression of SIRTl mRNA, inhibit the proliferation of C33A cells, suggesting that SIRTL has promoting abilities in human cervical cancer.

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

An overview of the latest research on AIM2 inflammasome and its role in infection, cancer, and autoimmunity is provided.

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

It is shown that the cell-cycle and apoptosis regulator E2F1 induces SirT1 expression at the transcriptional level and knockdown ofSirT1 by small interference RNA increases E1F1 transcriptional and apoptotic functions.

Caspase‐1‐induced pyroptotic cell death

The role of distinct inflammasomes, including NLRC4, NLRP3, and AIM2, as well as the role of the ASC focus in Caspase‐1 signaling are discussed, further reviewing the importance of pyroptosis in vivo as a potent mechanism to clear intracellular pathogens.