Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

  title={Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease},
  author={S. Ayton and Peng Lei and J. Duce and Bruce X. W. Wong and A. Sedjahtera and P. Adlard and A. Bush and D. Finkelstein},
  journal={Annals of Neurology},
  • S. Ayton, Peng Lei, +5 authors D. Finkelstein
  • Published 2013
  • Medicine
  • Annals of Neurology
  • Ceruloplasmin is an iron‐export ferroxidase that is abundant in plasma and also expressed in glia. We found a ∼80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro‐oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral… CONTINUE READING
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