Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

@article{Ayton2013CeruloplasminDA,
  title={Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease},
  author={S. Ayton and Peng Lei and J. Duce and Bruce X. W. Wong and A. Sedjahtera and P. Adlard and A. Bush and D. Finkelstein},
  journal={Annals of Neurology},
  year={2013},
  volume={73}
}
  • S. Ayton, Peng Lei, +5 authors D. Finkelstein
  • Published 2013
  • Medicine
  • Annals of Neurology
  • Ceruloplasmin is an iron‐export ferroxidase that is abundant in plasma and also expressed in glia. We found a ∼80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro‐oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral… CONTINUE READING
    147 Citations
    Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.
    • 15
    Does Ceruloplasmin Defend Against Neurodegenerative Diseases?
    • 17
    • PDF
    Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats
    • 6
    Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia
    • 16
    • Highly Influenced
    • PDF
    Cp/Heph mutant mice have iron‐induced neurodegeneration diminished by deferiprone
    • 23
    Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
    • 75
    • PDF
    Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid
    • 21
    • PDF

    References

    SHOWING 1-10 OF 31 REFERENCES
    Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury
    • 322
    • PDF
    Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention
    • 97
    • Highly Influential
    • PDF
    Ceruloplasmin metabolism and function.
    • 633
    Sequestration of iron by Lewy bodies in Parkinson’s disease
    • 184
    Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson’s disease
    • 45
    • Highly Influential
    Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease.
    • 94
    • Highly Influential
    • PDF
    Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
    • 101
    • Highly Influential