Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

@article{Ayton2013CeruloplasminDA,
  title={Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.},
  author={Scott Ayton and Peng Lei and James A Duce and Bruce X Wong and Amelia Sedjahtera and Paul A. Adlard and Ashley I. Bush and David Isaac Finkelstein},
  journal={Annals of neurology},
  year={2013},
  volume={73 4},
  pages={
          554-9
        }
}
Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia. We found a ∼80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro-oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral… CONTINUE READING
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