Ceruloplasmin copper induces oxidant damage by a redox process utilizing cell-derived superoxide as reductant.

@article{Mukhopadhyay1998CeruloplasminCI,
  title={Ceruloplasmin copper induces oxidant damage by a redox process utilizing cell-derived superoxide as reductant.},
  author={Chinmay K Mukhopadhyay and Paul L. Fox},
  journal={Biochemistry},
  year={1998},
  volume={37 40},
  pages={14222-9}
}
Oxidative damage by transition metals bound to proteins may be an important pathogenic mechanism. Ceruloplasmin (Cp) is a Cu-containing plasma protein thought to be involved in oxidative modification of lipoproteins. We have previously shown that Cp increased cell-mediated low-density lipoprotein (LDL) oxidation by a process requiring cell-derived… CONTINUE READING