Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.

@article{Callebaut2006CernunnosIW,
  title={Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.},
  author={Isabelle Callebaut and Laurent Malivert and Alain Fischer and Jean-Paul Mornon and Patrick Revy and Jean-Pierre de Villartay},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 20},
  pages={13857-60}
}
DNA double strand breaks are considered as the most harmful DNA lesions and are repaired by either homologous recombination or nonhomologous end joining (NHEJ). A new NHEJ factor, Cernunnos, has been identified, the defect of which leads to a severe immunodeficiency condition associated with microcephaly and other developmental defects in humans. This presentation is reminiscent to that of DNA-ligase IV deficiency and suggests a possible interplay between Cernunnos and the XRCC4 x DNA-ligase IV… CONTINUE READING

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