Cerium Oxide Nanoparticles Induce Oxidative Stress and Genotoxicity in Human Skin Melanoma Cells

@article{Ali2014CeriumON,
  title={Cerium Oxide Nanoparticles Induce Oxidative Stress and Genotoxicity in Human Skin Melanoma Cells},
  author={Daoud Ali and Saud Alarifi and Saad Saeed Alkahtani and Abdullah A. Alkahtane and Abdulaziz M Almalik},
  journal={Cell Biochemistry and Biophysics},
  year={2014},
  volume={71},
  pages={1643-1651}
}
Extensive applications of cerium oxide (CeO2) nanoparticles require a better understanding of their possible effects on human health. However, data demonstrating the effect of CeO2 nanoparticles on the human skin melanoma cell remain scanty. In the current study, we determined the mechanism through which CeO2 nanoparticles (APS <25 nm) induce toxicity in human skin melanoma cells (A375). The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] and neutral red uptake assays showed… CONTINUE READING

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