Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging

@inproceedings{Tripathy2010CerebrovascularEO,
  title={Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging},
  author={Debjani Tripathy and Xiangling Yin and Alma Christina S{\'a}nchez and Jinhua Luo and J Manuel Cifuentes Mart{\'i}nez and Paula Grammas},
  booktitle={Journal of Neuroinflammation},
  year={2010}
}
Most neurodegenerative diseases are age-related disorders; however, how aging predisposes the brain to disease has not been adequately addressed. The objective of this study is to determine whether expression of proteins in the cerebromicrovasculature related to inflammation, oxidative stress and neurotoxicity is altered with aging. Brain microvessels are isolated from Fischer 344 rats at 6, 12, 18 and 24 months of age. Levels of interleukin (IL)-1β and IL-6 RNA are determined by RT-PCR and… CONTINUE READING
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