Cerebrovascular events, secondary intracranial tumors, and mortality after radiotherapy for nonfunctioning pituitary adenomas: a subanalysis from the Dutch National Registry of Growth Hormone Treatment in Adults.

@article{Varsseveld2015CerebrovascularES,
  title={Cerebrovascular events, secondary intracranial tumors, and mortality after radiotherapy for nonfunctioning pituitary adenomas: a subanalysis from the Dutch National Registry of Growth Hormone Treatment in Adults.},
  author={Nad{\`e}ge C. van Varsseveld and Christa C van Bunderen and D H H Ubachs and Anton A. M. Franken and H. P. F. Koppeschaar and Aart Jan van der Lely and Madeleine L. Drent},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2015},
  volume={100 3},
  pages={1104-12}
}
CONTEXT Radiotherapy is frequently administered as adjuvant treatment in patients with clinically nonfunctioning pituitary adenomas (NFPAs). However, concerns have been raised about potential long-term side effects, including cerebrovascular events (CVEs) and secondary intracranial tumors. OBJECTIVE The aim of this study was to analyze the risk of CVEs, secondary intracranial tumors, and mortality in irradiated (IRR) NFPA patients, compared with NFPA patients who were not irradiated (non-IRR… CONTINUE READING
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