Cerebrovascular disorders: molecular insights and therapeutic opportunities

  title={Cerebrovascular disorders: molecular insights and therapeutic opportunities},
  author={Erik Storkebaum and Annelies Quaegebeur and Miikka Vikkula and Peter Carmeliet},
  journal={Nature Neuroscience},
Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological disorders. Here we will discuss molecular insights into neurological disorders resulting either from excessive vessel growth (cerebral vascular malformations) or improper vessel… CONTINUE READING