Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril.

@article{Jarden1984CerebrovascularAO,
  title={Cerebrovascular aspects of converting-enzyme inhibition II: Blood-brain barrier permeability and effect of intracerebroventricular administration of captopril.},
  author={J O Jarden and D. I. Barry and Marianne Juhler and David I. Graham and Svend Strandgaard and Olaf Bjarne Paulson},
  journal={Journal of hypertension},
  year={1984},
  volume={2 6},
  pages={599-604}
}
The blood-brain barrier permeability to captopril, and the cerebrovascular effects of intracerebroventricular administration of captopril, were studied in normotensive Wistar rats. The blood-brain barrier permeability-surface area product (PS), determined by an integral-uptake method, was about 1 X 10(-5) cm3/g/s in all brain regions studied. This was three… CONTINUE READING