Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.

@article{Cooper2016CerebrovascularDM,
  title={Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.},
  author={Leroy L. Cooper and Todd Woodard and Sigurdur E Sigurdsson and Mark A. van Buchem and Alyssa A. Torjesen and Lesley A. Inker and Thor Aspelund and Gudny Eiriksdottir and Tamara B. Harris and Vilmundur Gudnason and Lenore J. Launer and Gary F. Mitchell},
  journal={Hypertension},
  year={2016},
  volume={67 1},
  pages={
          176-82
        }
}
Aortic stiffness is associated with cognitive decline. Here, we examined the association between carotid-femoral pulse wave velocity and cognitive function and investigated whether cerebrovascular remodeling and parenchymal small vessel disease damage mediate the relation. Analyses were based on 1820 (60% women) participants in the Age, Gene/Environment Susceptibility-Reykjavik Study. Multivariable linear regression models adjusted for vascular and demographic confounders showed that higher… CONTINUE READING

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