Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease.

@article{Chalbot2009CerebrospinalFS,
  title={Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease.},
  author={Sonia Chalbot and Henrik Zetterberg and K Blennow and Tormod Fladby and Inge Grundke-Iqbal and Khalid Iqbal},
  journal={Clinical chemistry},
  year={2009},
  volume={55 12},
  pages={2171-9}
}
BACKGROUND The phospholipase A(2) (PLA2) family comprises multiple isoenzymes that vary in their physicochemical properties, cellular localizations, calcium sensitivities, and substrate specificities. Despite these differences, PLA2s share the ability to catalyze the synthesis of the precursors of the proinflammatory mediators. To investigate the potential of PLA2 as a biomarker in screening neuroinflammatory disorders in both clinical and research settings, we developed a PLA2 assay and… CONTINUE READING