Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys.

@article{Pendyala2009CerebrospinalFP,
  title={Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys.},
  author={Gurudutt Pendyala and Sunia A. Trauger and Ewa Kalisiak and Ronald J Ellis and Gary Siuzdak and Howard S. Fox},
  journal={Journal of proteome research},
  year={2009},
  volume={8 5},
  pages={2253-60}
}
The HIV-1-associated neurocognitive disorder occurs in approximately one-third of infected individuals. It has persisted in the current era of antiretroviral therapy, and its study is complicated by the lack of biomarkers for this condition. Since the cerebrospinal fluid is the most proximal biofluid to the site of pathology, we studied the cerebrospinal fluid in a nonhuman primate model for HIV-1-associated neurocognitive disorder. Here we present a simple and efficient liquid chromatography… CONTINUE READING
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