Cerebrospinal fluid production is reduced in healthy aging.

@article{May1990CerebrospinalFP,
  title={Cerebrospinal fluid production is reduced in healthy aging.},
  author={C. May and Jeffrey A. Kaye and John R Atack and Mark B. Schapiro and Robert P Friedland and Stanley I. Rapoport},
  journal={Neurology},
  year={1990},
  volume={40 3 Pt 1},
  pages={
          500-3
        }
}
In order to study age-related differences in cerebrospinal fluid (CSF) production in humans, we measured the rate of CSF production in 7 young (age 21 to 36 years) and 7 elderly (age 67 to 84 years) healthy volunteers, using a modified Masserman method. In addition, we evaluated CSF protein gradients by collecting CSF in serial fractions up to the 30th ml and assaying for total protein concentration. The mean rate of CSF production was significantly less in the elderly than in the young… CONTINUE READING

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