Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation.

@article{Shi2015CerebrospinalFP,
  title={Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation.},
  author={Min Shi and James Movius and Romel Dator and Patrick Aro and Yanchun Zhao and Catherine Pan and Xiangmin Lin and Theo K. Bammler and Tessandra H. Stewart and Cyrus P Zabetian and E. R. Peskind and S Hu and Joseph F Quinn and Douglas R. Galasko and Jing Zhang},
  journal={Molecular & cellular proteomics : MCP},
  year={2015},
  volume={14 3},
  pages={544-55}
}
Finding robust biomarkers for Parkinson disease (PD) is currently hampered by inherent technical limitations associated with imaging or antibody-based protein assays. To circumvent the challenges, we adapted a staged pipeline, starting from our previous proteomic profiling followed by high-throughput targeted mass spectrometry (MS), to identify peptides in human cerebrospinal fluid (CSF) for PD diagnosis and disease severity correlation. In this multicenter study consisting of training and… CONTINUE READING
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