Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration.

@article{Scherling2014CerebrospinalFN,
  title={Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration.},
  author={Carole S. Scherling and Tracey E Hall and Flora Berisha and Kristen M. Klepac and Anna M. Karydas and Giovanni Coppola and Joel H. Kramer and Gil D. Rabinovici and Michael Ahlijanian and Bruce L. Miller and William W. Seeley and Lea Tenenholz Grinberg and Howard Rosen and Jere E. Meredith and Adam L. Boxer},
  journal={Annals of neurology},
  year={2014},
  volume={75 1},
  pages={116-26}
}
OBJECTIVE Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD. METHODS CSF NfL, amyloid-β1-42 (Aβ42), tau, and phosphorylated tau concentrations were compared in 47 normal controls (NC), 8 asymptomatic gene carriers (NC2) of FTD-causing mutations, and 79 FTD (45 behavioral variant frontotemporal dementia [bvFTD], 18… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry • 2018
View 20 Excerpts
Highly Influenced

The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias

Alzheimer's Research & Therapy • 2017
View 5 Excerpts
Highly Influenced

Neurofilament light chain: a biomarker for genetic frontotemporal dementia

Annals of clinical and translational neurology • 2016
View 10 Excerpts
Highly Influenced

Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory

Annals of clinical and translational neurology • 2018
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss.

Journal of the neurological sciences • 2005
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…