Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy.

@article{Nicoli1996CerebrospinalFM,
  title={Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy.},
  author={François Nicoli and Jean Vion-Dury and Sylviane Confort-Gouny and Sophie Maillet and J. L. Gastaut and Patrick J. Cozzone},
  journal={Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  year={1996},
  volume={319 7},
  pages={623-31}
}
We have analyzed the cerebrospinal fluid (CSF) of 19 patients with multiple sclerosis (MS), 12 patients with degenerative dementia and 17 control patients using in vitro high resolution proton magnetic resonance spectroscopy (MRS) at 400 MHz. The CSF metabolic profile is slightly modified in MS patients (increased lactate and fructose concentrations, decreased creatinine and phenylalanine concentrations) and is not correlated with the intensity of the intrathecal inflammation. Proton MRS of CSF… CONTINUE READING

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