Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy.

@article{Romigi2010CerebrospinalFL,
  title={Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy.},
  author={Andrea Romigi and Monica Bari and Fabio Placidi and Maria Grazia Marciani and Marilena Malaponti and Federico Torelli and Francesca Izzi and Chiara Prosperetti and Silvana Zannino and Francesca Corte and Carlo Chiaramonte and M. Maccarrone},
  journal={Epilepsia},
  year={2010},
  volume={51 5},
  pages={768-72}
}
PURPOSE The endocannabinoid system is involved in excitatory/inhibitory balance mechanisms within the central nervous system (CNS). Growing evidence shows that its perturbation leads to development of epileptic seizures in experimental models, thus indicating that endocannabinoids play an intrinsic protective role in suppressing pathologic neuronal excitability. Experimental data also demonstrate that the endocannabinoid anandamide (AEA) can antagonize epileptic discharges in hippocampal tissue… CONTINUE READING
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