Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury.

@article{Au2012CerebrospinalFL,
  title={Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury.},
  author={Alicia K. Au and Rajesh K. Aneja and Michael J. Bell and H{\"u}lya A Bayir and Keri L Feldman and P. David Adelson and Ericka L. Fink and Patrick M Kochanek and Robert S B Clark},
  journal={Journal of neurotrauma},
  year={2012},
  volume={29 11},
  pages={2013-21}
}
High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochrome c may in part reflect the degree of necrosis and apoptosis present after traumatic brain injury (TBI), where both are felt to contribute to cell death and neurological… CONTINUE READING
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