Cerebrospinal fluid levels of chlorpromazine and its metabolites in schizophrenia


The concentrations of chlorpromazine and some of its metabolites in blood plasma and CSF from chlorpromazine-treated schizophrenics with different therapeutic results were studied. Compared to a good responder a poor responder showed very high levels of the inactive metabolite chlorpromazine sulphoxide in the CSF. 
DOI: 10.1007/BF00431052


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