Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis.


We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/serum vitamin E ratio did not differ significantly between the two study groups. The serum levels of vitamin E and the serum vitamin E/cholesterol ratio were significantly lower in MS patients when compared with controls (P < 0.05 and P < 0.01, respectively). These values were not correlated with age, age at onset and duration of the disease in the patients group. These results suggest that CSF vitamin E concentrations are not a marker of activity of MS activity.


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@article{JimnezJimnez1998CerebrospinalFL, title={Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis.}, author={F{\'e}lix Javier Jim{\'e}nez-Jim{\'e}nez and F de Bustos and Jose Antonio Navas Molina and Clara de Andr{\'e}s and Teresa Gasalla and M. Ort{\'i}-Pareja and Mart{\'i}n Zurdo and J M Pe{\~n}a Porta and F Castellano-Mill{\'a}n and Joaqu{\'i}n Arenas and Rafael Enr{\'i}quez de Salamanca}, journal={Neuroscience letters}, year={1998}, volume={249 1}, pages={65-7} }