Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery

@article{Liu2006CerebrospinalFI,
  title={Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery},
  author={Pinghuang Liu and Lola C. Hudson and Mary B. Tompkins and Thomas Wilhelm Vahlenkamp and Brenda A Colby and Cyndi Rundle and Rick B. Meeker},
  journal={Journal of NeuroVirology},
  year={2006},
  volume={12},
  pages={294-306}
}
Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF barrier. This raises the concern whether this route can establish a stable viral reservoir and also be a source of virus capable of reseeding peripheral systems. To examine this… CONTINUE READING

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